My Ultimate Pet

Science & evidence

Promising is notthe same as proven.

Every element of a plan is labelled by how much is actually known about it in dogs and cats. Each source below states what it supports — and, just as importantly, what it does not establish.

A mature cat stretching on a wooden floor near a sunlit doorway

Source library

Last reviewed: July 2026

  • Established FoundationsPeer-reviewed study

    Lifelong maintenance of lean body condition and lifespan in dogs

    Journal of the American Veterinary Medical Association · Labrador Retrievers (paired feeding cohort) · 2002

    What it supports
    Maintaining a lean body condition across life was associated with a longer median lifespan and later onset of chronic disease signs.
    What it does not establish
    Does not establish that any supplement, compounded preparation or protocol extends lifespan.
  • Established FoundationsClinical guideline

    Multimodal management of canine osteoarthritis

    Veterinary specialty consensus guidance · Dogs (clinical population) · 2018–2023

    What it supports
    Weight control, controlled exercise, rehabilitation and veterinary-directed pain management improve comfort and function.
    What it does not establish
    Does not establish reversal of joint disease or equivalence between rehabilitation and pharmaceutical care.
  • Established FoundationsReview article

    Value of longitudinal monitoring in mature and senior cats

    Feline internal medicine literature · Cats (clinical population) · 2021

    What it supports
    Regular examination and laboratory monitoring in mature cats supports earlier detection and better-informed care decisions.
    What it does not establish
    Does not establish that monitoring alone changes long-term survival for any individual cat.
  • Translational SignalsPreclinical study

    Cellular senescence and healthspan in mammalian models

    Aging biology literature · Rodent models · 2016–2023

    What it supports
    Mechanistic rationale for how clearance of senescent cells may influence measures of physical function in laboratory models.
    What it does not establish
    Does not establish safety, dosing or benefit in pet dogs or cats. No target-species outcome data.
  • Translational SignalsPreclinical study

    mTOR pathway modulation and age-related measures in dogs

    Comparative aging research · Dogs (small research cohorts) · 2017–2024

    What it supports
    Early exploratory work examining whether pathway modulation shifts selected age-related measures.
    What it does not establish
    Does not establish clinical benefit, appropriate candidates or long-term safety in companion dogs.
  • Investigational OptionsReview article

    Regenerative adjuncts in veterinary orthopaedics

    Veterinary surgery literature · Dogs and horses (heterogeneous studies) · 2019–2024

    What it supports
    Mixed early findings with wide variation in preparation, protocol and outcome measurement.
    What it does not establish
    Does not establish standardised benefit; regulatory status and product consistency remain unresolved.

The reading list

What the researchsays aboutyour pet.

What the research says about your pet

Each entry states how the work applies to dogs and cats, the benefit it describes, and the line it does not cross. Follow any link to read the source yourself.

  • Metabolic PenJAVMA (Kealy et al.) · 2002

    Effects of diet restriction on life span and age-related changes in dogs

    Labrador Retrievers, 14-year paired cohort

    The single strongest longevity finding in companion dogs: littermate pairs fed 25% less across life were followed to end of life.

    The benefit described
    Lean-fed dogs lived a median 1.8 years longer and showed later onset of visible osteoarthritis.
    Where it stops
    Body condition, not any injectable or supplement, produced the effect. One breed, one facility.
    Read the source
  • Cellular PenDog Aging Project · 2021–ongoing

    TRIAD — Test of Rapamycin In Aging Dogs

    Companion dogs, ≥7 years, owner-enrolled

    The first large, double-blind, placebo-controlled longevity trial run in pet dogs living at home rather than in a laboratory.

    The benefit described
    Owners report a second benefit alongside the science: full cardiac, cognitive and blood screening surfaced conditions their dogs were not yet symptomatic for.
    Where it stops
    Results are not yet reported. Enrolment in a trial is not the same as an available product.
    Read the source
  • Cellular PenGeroScience (Urfer et al.) · 2017

    Short-term rapamycin in middle-aged companion dogs

    24 middle-aged pet dogs

    A safety-and-feasibility trial asking whether an ageing-pathway intervention can be given to household dogs at all.

    The benefit described
    No significant adverse effects at the doses used, with echocardiographic measures trending in the treated group.
    Where it stops
    Ten weeks, 24 dogs, no lifespan endpoint. A safety signal, not an outcome.
    Read the source
  • Cellular PenAging-biology literature · 2016–2024

    NAD+ decline with age and mitochondrial function

    Mammalian models; canine work emerging

    Explains why energy, recovery and cognition drift in older animals: NAD+ availability falls in multiple tissues with age.

    The benefit described
    Restoring NAD+ availability improves measures of mitochondrial output in model organisms.
    Where it stops
    No controlled healthspan or lifespan data in pet dogs or cats. Mechanism only.
    Read the source
  • Mobility PenPreclinical orthopaedic literature · 2011–2023

    Pentadecapeptide BPC-157 and tendon-to-bone healing

    Rat and ex-vivo tendon models

    The mechanistic basis behind the most-requested research category — stiffness after rest, slower stairs, shorter walks.

    The benefit described
    Accelerated tendon fibroblast outgrowth and improved tendon-to-bone healing in the models studied.
    Where it stops
    Rodent models. No controlled mobility outcomes in pet dogs or cats, and no established dosing.
    Read the source
  • Mobility PenVeterinary consensus guidance · 2018–2023

    Multimodal management of canine osteoarthritis

    Dogs, clinical population

    The established floor under any mobility research: weight, controlled exercise, rehabilitation, and veterinary-directed pain control.

    The benefit described
    Consistently improves comfort and function — the best-supported intervention available to a pet family today.
    Where it stops
    Does not reverse joint disease, and is not replaced by anything investigational.
    Read the source

In their words

Families alreadydoing thiswork.

Families already doing this work

Quoted from published interviews with owners enrolled in companion-animal longevity research. These are not testimonials for our products, and no outcome is implied.

  • “I was interested because Madi was getting older and I knew that this study was a longevity study for dogs. I thought if I could extend her life and have good quality of life, that would be really fabulous.”

    JoAnna

    Seattle, WA — University of Washington retiree

    Madi, Akita-Rottweiler mix, adopted 2009

    Dog Aging Project — TRIAD Tails
  • “I'm thankful that I learned she had high blood pressure, because it's treatable, and I don't know that I would have known that otherwise.”

    JoAnna

    On the trial's baseline screening

    Madi, screened at WSU College of Veterinary Medicine

    Dog Aging Project — TRIAD Tails
  • “My goal is just to provide them with the best quality of life for as long as possible. I've certainly been provided with second chances in life, and I'd like to offer that to pets.”

    Linda

    West Des Moines, IA — senior analytics analyst

    Sadie, lab/husky mix, adopted from a shelter in 2020

    Dog Aging Project — TRIAD Tails
  • “I ended up realizing the importance of quality of life as they get older. I learned that Zoe was a lot healthier than I thought she was.”

    Bill

    Georgetown, TX — enrolled Zoe at age 10

    Zoe, Labrador-Rottweiler mix, raised from a puppy

    Dog Aging Project — TRIAD Tails
  • “Through participation, Sadie was potentially able to give back and contribute positively to the health, longevity and quality of life of others.”

    Linda

    After Sadie's graduation from the trial

    Sadie, 2020–2025

    Dog Aging Project — TRIAD Tails
An older dog looking out over an open meadow at golden hour

The point of all of it

What would moregood years looklike for them?

What would more good years look like for them?

One more trail. One more favorite window. Thousands more ordinary moments—the ones that never feel ordinary later.

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